Anette Johansson

7521462, Apr 21, 2009

Feb 11, 2005

10/597795

Serge Louis Boulet - Fishers IN, US
Barry Peter Clark - Basingstoke, GB
John Fairhurst - Basingstoke, GB
Peter Thaddeus Gallagher - Basingstoke, GB
Anette Margareta Johansson - Indianapolis IN, US
Maria Ann Whatton - Basingstoke, GB
Virginia Ann Wood - Basingstoke, GB

Eli Lilly and Company - Indianapolis IN

A61K 31/4468
A61K 31/4535

514321, 514324, 514326, 546209, 546212

The present invention provides compounds of formula (I) where n, R1, R2, R3, R4, R5 and Heteroaryl are defined herein. The compounds are inhibitors of the uptake of one or more monoamines selected from serotonin, norepinephrine and dopamine and, as such, may be useful in the treatment of disorders of the central and/or peripheral nervous system.

8173821, May 8, 2012

Apr 6, 2010

12/754800

Nicolas Jacques Francois Dreyfus - Basingstoke, GB
Sandra Ann Filla - Franklin IN, US
Anette Margareta Johansson - Indianapolis IN, US
Thierry J. Masquelin - Westfield IN, US
Jikesh Arvind Shah - Greenwood IN, US
Eric George Tromiczak - Indianapolis IN, US
Magnus Wilhelm Walter - Basingstoke, GB

Eli Lilly and Company - Indianapolis IN

C07D 213/62
A61K 31/44

546300, 514335

A serotonin and norepinephrine reuptake inhibitor of the formula:.

6747156, Jun 8, 2004

Dec 4, 2002

10/221175

Anette Johansson - Indianapolis IN
Torgny Svensson - Lidingö, SE

Independent Pharmaceutica AB - Taby

C07D40104

5462764

A method of producing a 6-substituted (S)-nicotine derivative with the general formula (III), wherein R is an optionally substituted alkyl, alkenyl, alkynyl, amido or amino group, optionally coupled to a carrier protein, is disclosed. An intermediate compound useful in the method is also comprised by the invention. The formula of the compound is (A) in which A represents the cationic radical of an organic nitrogen base, Y represents an anion formed by an electrophilic compound.

2007007, Mar 29, 2007

Feb 18, 2005

10/597835

Serge Boulet - Fishers IN, US
Anette Johansson - Indianapolis IN, US
Sarah Smith - Indianapolis IN, US

Eli Lilly and Company - Indianapolis IN

A61K 31/5375
A61K 31/445
A61K 31/40
A61K 31/137
C07D 211/06

514237800, 514317000, 514408000, 514651000, 514649000, 548561000, 546205000, 546229000, 544158000, 544162000, 564341000, 564349000

The present invention relates to inhibitors of serotonin and/or norepinephrine reuptake and specifically provides compounds of formula (I): wherein A is selected from —O— and —S—; X is selected from C-Calkyl, C-Calkenyl, and C-Ccycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from phenyl, pyrrolidinyl, piperidinyl, morpholinyl, halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, —CF, —CN and —CONH; Y is selected from (a), (b), (c), (d), (e), (f) where R, Rand Rare independently selected from hydrogen, halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, nitro, acetyl, —CF, —SCFand cyano; Rand Rare independently selected from halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, nitro, acetyl, —CF, —SCFand cyano; Ris selected from chloro, bromo, iodo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, nitro, acetyl, —CF, —SCFand cyano; Rand Rare each independently hydrogen or C-Calkyl; or pharmaceutically acceptable salts thereof; or compositions thereof and methods of using the same.

7410982, Aug 12, 2008

Oct 24, 2003

10/532765

Serge Louis Boulet - Fishers IN, US
Sandra Ann Filla - Brownsburg IN, US
Peter Thaddeus Gallagher - Basingstoke, GB
Kevin John Hudziak - Indianapolis IN, US
Anette Margareta Johansson - Indianapolis IN, US
Rushad E. Karanjawala - Zionsville IN, US
John Joseph Masters - Fishers IN, US
Brian Michael Mathes - Indianapolis IN, US
Richard Edmund Rathmell - Basingstoke, GB
Maria Ann (nee Fagan) Whatton - Basingstoke, GB
Victor Matassa - Heidelberg, DE
Chad Nolan Wolfe - Noblesville IN, US

Eli Lilly and Company - Indianapolis IN

A61K 31/4365
C07D 409/02

514338, 5462811

There is provided a heretoaryloxy/thio 3-substituted propanamine compound of formula (I) wherein A is selected from —O— and —S—; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C-Calkyl and C-Calkoxy, thienyl optionally substituted with up to 3 substituents each independently selected from halo and C-Calkyl, and C-Calkyl, C-Calkenyl, C-Ccycloalkyl and C-Ccycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C-Calkyl, C-Calkoxy, C-Calkyl —S(O)— where n is 0, 1 or 2, —CF, —CN and —CONH; Y is selected from dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, and thienopyridyl, each of which may be optionally substituted with up to 4 or, where possible, up to 5 substituents each independently selected from halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, nitro acetyl, —CF, —SCFand cyano; Z is selected from H, ORor F, wherein Ris selected from H, C-Calkyl and phenyl CCalkyl; Rand Rare each independently H or C-Calkyl; and pharmaceutically acceptable salts thereof.

7410996, Aug 12, 2008

Oct 24, 2003

10/533328

Serge Louis Boulet - Fishers IN, US
Sandra Ann Filla - Brownsburg IN, US
Peter Thaddeus Gallagher - Surrey, GB
Kevin John Hudziak - Indianapolis IN, US
Anette Margareta Johansson - Indianapolis IN, US
Rushad E. Karanjawala - Zionsville IN, US
John Joseph Masters - Fishers IN, US
Victor Giulio Matassa - Hirschberg, DE
Brian Michael Mathes - Indianapolis IN, US
Richard Edmund Rathmell - Ash Vale, GB
Maria Ann Whatton - Bracknell, GB
Chad Nolan Wolfe - Noblesville IN, US

Eli Lilly and Company - Indianapolis IN

A61K 31/381
C07D 333/64

514443, 549 51

There is provided a compound of formula (I) wherein A is selected from —O— and —S—; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C-Calkyl and C-Calkoxy, thienyl optionally substituted with up to 3 substituents each independently selected from halo and C-Calkyl, and C-Calkyl, C-Calkenyl, C-Ccycloalkyl and C-Ccycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, —CF, —CN and —CONH; Y is selected from phenyl, naphthyl, dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, thienopyridyl, indanyl, 1,3-benzodioxolyl, benzothienyl, indolyl and benzofuranyl, each of which may be optionally substituted with up to 4 or, where possible, up to 5 substituents each independently selected from halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, nitro, acetyl, —CF, —SCFand cyano; and when Y is indolyl it may be substituted or further substituted by an N-substituent selected from C-Calkyl; Z is selected from ORor F, wherein Ris selected from H, C-Calkyl and phenyl C-Calkyl; Rand Rare each independently H or C-Calkyl; and pharmaceutically acceptable salts thereof with the proviso that when Y is optionally substituted phenyl or optionally substituted 1,3-benzodioxolyl and Z is ORand X is optionally substituted phenyl then A is —S—.

7417064, Aug 26, 2008

Oct 24, 2003

10/532657

Serge Louis Boulet - Fishers IN, US
Sandra Ann Filla - Brownsburg IN, US
Peter Thaddeus Gallagher - Surrey, GB
Kevin John Hudziak - Indianapolis IN, US
Anette Margareta Johansson - Indianapolis IN, US
Rushad E. Karanjawala - Zionsville IN, US
John Joseph Masters - Fishers IN, US
Victor Giulio Matassa - Hirschberg, DE
Brian Michael Mathes - Indianapolis IN, US
Richard Edmund Rathmell - Ash Vale, GB
Maria Ann Whatton - Bracknell, GB
Chad Nolan Wolfe - Noblesville IN, US

Eli Lilly and Company - Indianapolis IN

A61K 31/381
C07D 333/64

514443, 549 51

There is provided a compound of formula (I) wherein A is selected from —O— and —S—; X is selected from C-Calkyl, C-Calkenyl, C-Ccycloalkyl and C-Ccycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, —CF, —CN and —CONH; Y is selected from phenyl, naphthyl, dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, thienopyridyl, indanyl, 1,3-benzodioxolyl, benzothienyl, indolyl and benzofuranyl, each of which may be optionally substituted with up to 4 or, where possible, 5 substituents each independently selected from halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, nitro, acetyl, —CF, —SCFand cyano; and when Y is indolyl it may be substituted or further substituted by an N-substituent selected from C-Calkyl; Z is selected from H, ORor F, wherein Ris selected from H, C-Calkyl and phenyl C-Calkyl; Rand Rare each independently H or C-Calkyl; with the proviso that, when Z is H, then Y may not be optionally substituted phenyl or optionally substituted naphthyl.